Magnesium Calm uses Magtein®, a magnesium chelated to threonic acid (magnesium L-threonate), a highly bioavailable form that crosses the blood-brain barrier. In comparison to other forms of magnesium, this form increases magnesium levels more effectively. By supplementing the brain with magnesium L-threonate, it may be possible to support cognitive abilities and decrease common age-related memory declines.
The supplemental form of magnesium called magnesium L-threonate is studied to be more effective at crossing the blood-brain barrier to support brain health and normal cognitive function. There are more than 300 enzymes in the body that rely on magnesium as a cofactor. Magnesium plays many roles in the body, including acting as an intracellular cofactor. Magnesium has several functions that promote normal brain and cognitive function.
Brain health and Magnesium
Magnesium Calm contains magnesium L-threonate, a form of magnesium studied at MIT for 10 years. The ability of magnesium L-threonate to cross the blood-brain barrier makes it unique. Together with calcium, magnesium optimizes nerve-to-nerve signaling at the synapses where nerve endings meet.
We learn by quickly forming new synapses and removing old ones, a trait called neuronal plasticity. Synaptic density, or the number of synapses present in the brain, determines how well we can remember. Studies at MIT have shown that magnesium L-threonate improves both neuronal plasticity and synaptic density, and therefore, both learning and memory. Additionally, magnesium L-threonate may help people recover from post-traumatic stress disorder (PTSD) and age-related memory loss. (1)(2)
In order for your brain and body to communicate, magnesium plays an important role. N-methyl-D-aspartate (NMDA) receptors are found on nerve cells and are important for brain development, memory, and learning. (3)
The NMDA receptors in healthy adults are protected by magnesium, which prevents weak signals from activating them unnecessarily. NMDA receptors are less blocked when magnesium levels are low. In other words, they are more likely to be stimulated than they need to be. Overstimulation can cause nerve cell death and brain damage. (4)
Magnesium and Anxiety
Magnesium may help treat and prevent anxiety, according to some research. One study found that increased magnesium intake was associated with a lower risk of depression and anxiety in 3,172 adults. In addition, magnesium deficiency may exacerbate anxiety symptoms by increasing your body’s susceptibility to stress. (5)(6)
In a study on 46 older adults, those taking a magnesium supplement daily fell asleep faster. They also noticed improved sleep quality and decreased insomnia symptoms. (11)
Several neurotransmitters involved in sleep, such as gamma-aminobutyric acid, are regulated by magnesium, which is used as a natural remedy for insomnia. Sleep can be affected by nerve activity, which can be calmed down by GABA. (12)
Magnesium supplements reduced the time it took older adults with insomnia to fall asleep by 17 minutes on average. There was also an association between increased intake of this mineral and improved sleep quality and duration in another study of nearly 4,000 adults. Furthermore, another study found that women who consumed more magnesium during the day were less likely to fall asleep during the day. (13)(14)
Combating Depression Symptoms
Depression symptoms have also been linked to low magnesium levels. Researchers found that adults aged 65 and under with the lowest intake of magnesium had a 22% greater risk of developing this condition in a study involving over 8,800 people. (15)
This is due to magnesium’s ability to regulate brain function and mood. Magnesium supplementation has been shown to reduce depression symptoms in several studies. It has even been found to be as effective as antidepressants in some studies. (16)